BPC-157

BPC-157 (Body Protection Compound-157) is a pentadecapeptide consisting of 15 amino acids, derived from a protective protein found in human gastric juice. First discovered in 1993, it has been extensively studied for its potential tissue repair, wound healing, and cytoprotective properties.

This stable gastric pentadecapeptide has attracted significant research interest for its wide-ranging effects on connective tissues, tendons, ligaments, muscles, and the gastrointestinal system. Studies suggest it may promote angiogenesis and modulate nitric oxide pathways.

Fun Facts & History

• "The Wolverine Peptide": BPC-157 earned this nickname due to its remarkable healing properties observed in research—much like the comic book character's regenerative abilities
• Stomach Origin: Derived from a protective protein found in human gastric juice—your stomach naturally makes a version of this compound to protect and heal its lining
• Croatian Discovery: First isolated and studied by Croatian scientists in the early 1990s at the University of Zagreb, where research continues to this day
• 544 Studies: One of the most extensively studied peptides with over 500 published research papers spanning three decades
• The "Body Protection" Name: BPC stands for Body Protection Compound—named for its cytoprotective effects observed across multiple organ systems in research

Animal Research Findings

• Tendon/Ligament: Rat studies show accelerated healing of Achilles tendon, MCL, and other connective tissues with improved tensile strength
• GI Protection: Rodent models demonstrate protection against NSAID-induced gastric ulcers, intestinal damage, and inflammatory bowel conditions
• Muscle Healing: Faster recovery from muscle crush injuries and transections in animal models, with enhanced regeneration markers
• Bone Repair: Improved fracture healing and bone-to-tendon junction repair observed in preclinical studies
• Neuroprotection: Studies show potential benefits in rodent models of nerve damage, brain injury, and dopaminergic system protection

Potential Future Applications (If Clinical Trials Succeed)

• Sports Medicine: If trials progress, could support tendon/ligament injury recovery protocols for athletes and active individuals
• Gut Health: IBD, gastric ulcers, leaky gut syndrome, and other GI therapies where mucosal healing is critical
• Post-Surgical Recovery: Accelerated healing after orthopedic procedures, potentially reducing recovery time and complications
• Neuroprotection: Peripheral nerve injury recovery, traumatic brain injury support, and neurodegenerative condition research

Year	Focus	Finding	Source
2024	Interstitial Cystitis Pilot	83% improvement in symptom scores	Clinical Trial
2025	IV Safety Study	Tolerability and safety profile assessment	Ongoing
2024	Sports Medicine Review	Comprehensive review of tendon/ligament research	Sports Med Review
2023	GI Protection	Cytoprotective effects on gastric mucosa	Preclinical