🧬 Epitalon

Epithalon / Epitalon (AEDG peptide) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) that has been studied for over 25 years for its potential role in telomerase activation and telomere support. Originally developed from Russian longevity research at the St. Petersburg Institute of Bioregulation and Gerontology, Epitalon is based on the naturally occurring epithalamin extracted from the pineal gland.

Research has focused on its ability to stimulate telomerase production, the enzyme responsible for maintaining telomere length. Telomeres are protective caps at the ends of chromosomes that shorten with each cell division, and their length is associated with biological aging.

✨ Fun Facts & History

• Soviet Longevity Project: Epitalon was developed by Russian scientist Professor Vladimir Khavinson as part of Soviet/Russian longevity research programs
• 30+ Years Clinical Use: Has been used clinically in Russia for over 3 decades, primarily for age-related conditions
• The Pineal Connection: Works by stimulating the pineal gland, which is sometimes called the "third eye" or "seat of the soul" in various traditions
• Telomere Extension: One of the few compounds shown to actually lengthen telomeres (the "caps" on chromosomes that shorten with age)
• 25 Year Patent Anniversary: June 2025 marked 25 years since Epitalon was patented, with extensive research during that time

🐭 Animal Research Findings

• Lifespan Extension: Aged rat studies showed increased maximum lifespan and delayed age-related changes
• Telomerase Activation: Campbell rat studies demonstrated reactivation of telomerase in somatic cells
• Pineal Function: Improved melatonin production and circadian rhythm regulation in aged animals
• Cancer Prevention: Some rodent studies suggest reduced tumor incidence, though more research needed
• Retinal Protection: Animal models of retinal degeneration showed protective effects

🔮 Potential Future Applications (If Clinical Trials Succeed)

• Longevity Medicine: Anti-aging protocols if Western clinical trials validate Russian data
• Ophthalmology: Retinal degeneration (already used clinically in Russia for Retinitis pigmentosa)
• Sleep Disorders: Melatonin regulation and circadian rhythm support
• Cellular Rejuvenation: Broader anti-aging and healthspan extension research

*Case study result, individual results may vary

Year	Focus	Finding	Source
2025	Telomere Extension	Confirmed telomere extension in cellular models	Biogerontology
2024	Biological Age	7.9-year reduction in biological age markers	Case Report
2003	Retinitis Pigmentosa	162 patients showed visual function improvements	Russian Clinical
2003	Telomerase Activity	Reactivation of telomerase in somatic cells	PubMed